Protein name:
High affinity nerve growth factor receptor ;
Alternative:
Neurotrophic tyrosine kinase receptor type 1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with KIDINS220 and NGFR. Can form a ternary complex with NGFR and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1.
Function:
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Endocytosed to the endosomes upon treatment of cells with NGF.
Protein Attributes:
50:
MLRGQRLGQL | GWHRPAAGLG | SLMTSLMLAC | ASAASCREVC | CPVGPSGLRC |
100:
TRAGSLDTLR | GLRGAGNLTE | LYVENQQHLQ | RLEFEDLQGL | GELRSLTIVK |
150:
SGLRFVAPDA | FRFTPRLSHL | NLSSNALESL | SWKTVQGLSL | QDLTLSGNPL |
200:
HCSCALFWLQ | RWEQEGLCGV | HTQTLHDSGP | GDQFLPLGHN | TSCGVPTVKI |
250:
QMPNDSVEVG | DDVFLQCQVE | GLALQQADWI | LTELEGAATV | KKFGDLPSLG |
300:
LILVNVTSDL | NKKNVTCWAE | NDVGRAEVSV | QVSVSFPASV | HLGLAVEQHH |
350:
WCIPFSVDGQ | PAPSLRWLFN | GSVLNETSFI | FTQFLESALT | NETMRHGCLR |
400:
LNQPTHVNNG | NYTLLAANPY | GQAAASVMAA | FMDNPFEFNP | EDPIPVSFSP |
450:
VDGNSTSRDP | VEKKDETPFG | VSVAVGLAVS | AALFLSALLL | VLNKCGQRSK |
500:
FGINRPAVLA | PEDGLAMSLH | FMTLGGSSLS | PTEGKGSGLQ | GHIMENPQYF |
550:
SDTCVHHIKR | QDIILKWELG | EGAFGKVFLA | ECYNLLNDQD | KMLVAVKALK |
600:
EASENARQDF | QREAELLTML | QHQHIVRFFG | VCTEGGPLLM | VFEYMRHGDL |
650:
NRFLRSHGPD | AKLLAGGEDV | APGPLGLGQL | LAVASQVAAG | MVYLASLHFV |
700:
HRDLATRNCL | VGQGLVVKIG | DFGMSRDIYS | TDYYRVGGRT | MLPIRWMPPE |
750:
SILYRKFSTE | SDVWSFGVVL | WEIFTYGKQP | WYQLSNTEAI | ECITQGRELE |
799:
RPRACPPDVY | AIMRGCWQRE | PQQRLSMKDV | HARLQALAQA | PPSYLDVLG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
Rat
ELISA Kit for Mouse High affinity nerve growth factor receptor
ELISA Kit for Mouse High affinity nerve growth factor receptor
ELISA Kit for Mouse High affinity nerve growth factor receptor
ELISA Kit for Mouse High affinity nerve growth factor receptor
CLIA Kit for Mouse High affinity nerve growth factor receptor
CLIA Kit for Mouse High affinity nerve growth factor receptor
CLIA Kit for Mouse High affinity nerve growth factor receptor
CLIA Kit for Mouse High affinity nerve growth factor receptor
Polyclonal Antibody for Mouse High affinity nerve growth factor receptor
Polyclonal Antibody for Mouse High affinity nerve growth factor receptor
Polyclonal Antibody for Mouse High affinity nerve growth factor receptor
Polyclonal Antibody for Mouse High affinity nerve growth factor receptor
Monoclonal Antibody for Mouse High affinity nerve growth factor receptor
Monoclonal Antibody for Mouse High affinity nerve growth factor receptor
Monoclonal Antibody for Mouse High affinity nerve growth factor receptor
Monoclonal Antibody for Mouse High affinity nerve growth factor receptor
Protein for Mouse High affinity nerve growth factor receptor
Protein for Mouse High affinity nerve growth factor receptor
Protein for Mouse High affinity nerve growth factor receptor
Protein for Mouse High affinity nerve growth factor receptor
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Embryo .
tissue :
Sympathetic ganglion .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE;FUNCTION IN DEVELOPMENT OF THE NERVOUS SYSTEM
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN SYMPATHETIC NEURONS SURVIVAL;DEVELOPMENTAL STAGE
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION;ENZYME REGULATION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION;INTERACTION WITH SH2D1A
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN NGF AND NTF3 SIGNALING;ENZYME REGULATION;SUBCELLULAR LOCATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION