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Index > Protein center > Ntrk1(Gene name) > Mouse
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  • Ntrk1 (Gene name),
  • High affinity nerve growth factor receptor (Protein name ),  NTRK1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Ntrk1;
    Protein name:
    High affinity nerve growth factor receptor;
    Alternative:
    Neurotrophic tyrosine kinase receptor type 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with KIDINS220 and NGFR. Can form a ternary complex with NGFR and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1.
    Function:
    Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Endocytosed to the endosomes upon treatment of cells with NGF.
    Protein Attributes:
    Sequence length:
    799
    Sequence:
    50:
    MLRGQRLGQL | GWHRPAAGLG | SLMTSLMLAC | ASAASCREVC | CPVGPSGLRC | 
    100:
    TRAGSLDTLR | GLRGAGNLTE | LYVENQQHLQ | RLEFEDLQGL | GELRSLTIVK | 
    150:
    SGLRFVAPDA | FRFTPRLSHL | NLSSNALESL | SWKTVQGLSL | QDLTLSGNPL | 
    200:
    HCSCALFWLQ | RWEQEGLCGV | HTQTLHDSGP | GDQFLPLGHN | TSCGVPTVKI | 
    250:
    QMPNDSVEVG | DDVFLQCQVE | GLALQQADWI | LTELEGAATV | KKFGDLPSLG | 
    300:
    LILVNVTSDL | NKKNVTCWAE | NDVGRAEVSV | QVSVSFPASV | HLGLAVEQHH | 
    350:
    WCIPFSVDGQ | PAPSLRWLFN | GSVLNETSFI | FTQFLESALT | NETMRHGCLR | 
    400:
    LNQPTHVNNG | NYTLLAANPY | GQAAASVMAA | FMDNPFEFNP | EDPIPVSFSP | 
    450:
    VDGNSTSRDP | VEKKDETPFG | VSVAVGLAVS | AALFLSALLL | VLNKCGQRSK | 
    500:
    FGINRPAVLA | PEDGLAMSLH | FMTLGGSSLS | PTEGKGSGLQ | GHIMENPQYF | 
    550:
    SDTCVHHIKR | QDIILKWELG | EGAFGKVFLA | ECYNLLNDQD | KMLVAVKALK | 
    600:
    EASENARQDF | QREAELLTML | QHQHIVRFFG | VCTEGGPLLM | VFEYMRHGDL | 
    650:
    NRFLRSHGPD | AKLLAGGEDV | APGPLGLGQL | LAVASQVAAG | MVYLASLHFV | 
    700:
    HRDLATRNCL | VGQGLVVKIG | DFGMSRDIYS | TDYYRVGGRT | MLPIRWMPPE | 
    750:
    SILYRKFSTE | SDVWSFGVVL | WEIFTYGKQP | WYQLSNTEAI | ECITQGRELE | 
    799:
    RPRACPPDVY | AIMRGCWQRE | PQQRLSMKDV | HARLQALAQA | PPSYLDVLG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse High affinity nerve growth factor receptor
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    ELISA Kit for Mouse High affinity nerve growth factor receptor
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    ELISA Kit for Mouse High affinity nerve growth factor receptor
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    ELISA Kit for Mouse High affinity nerve growth factor receptor
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    E9557r
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    CLIA Kit for Mouse High affinity nerve growth factor receptor
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    CLIA Kit for Mouse High affinity nerve growth factor receptor
    Cat.:
    U9557r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse High affinity nerve growth factor receptor
    Cat.:
    U9557m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse High affinity nerve growth factor receptor
    Cat.:
    U9557h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse High affinity nerve growth factor receptor
    Cat.:
    P9557Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse High affinity nerve growth factor receptor
    Cat.:
    P9557Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse High affinity nerve growth factor receptor
    Polyclonal Antibody for Mouse High affinity nerve growth factor receptor
    Monoclonal Antibody for Mouse High affinity nerve growth factor receptor
    Monoclonal Antibody for Mouse High affinity nerve growth factor receptor
    Monoclonal Antibody for Mouse High affinity nerve growth factor receptor
    Monoclonal Antibody for Mouse High affinity nerve growth factor receptor
    Protein for Mouse High affinity nerve growth factor receptor
    Protein for Mouse High affinity nerve growth factor receptor
    Protein for Mouse High affinity nerve growth factor receptor
    Protein for Mouse High affinity nerve growth factor receptor

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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Sympathetic ganglion.
    2. 2.
      "Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene."
      Smeyne R.J. , Klein R. , Schnapp A. , Long L.K. , Bryant S. , Lewin A. , Lira S.A. , Barbacid M.
      Nature368:246-249(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN DEVELOPMENT OF THE NERVOUS SYSTEM
    3. 3.
      "TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo."
      Fagan A.M. , Zhang H. , Landis S. , Smeyne R.J. , Silos-Santiago I. , Barbacid M.
      J. Neurosci.16:6208-6218(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SYMPATHETIC NEURONS SURVIVAL;DEVELOPMENTAL STAGE
    4. 4.
      "p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation."
      Makkerh J.P. , Ceni C. , Auld D.S. , Vaillancourt F. , Dorval G. , Barker P.A.
      EMBO Rep.6:936-941(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;ENZYME REGULATION
    5. 5.
      "SLAM-associated protein as a potential negative regulator in Trk signaling."
      Lo K.Y. , Chin W.H. , Ng Y.P. , Cheng A.W. , Cheung Z.H. , Ip N.Y.
      J. Biol. Chem.280:41744-41752(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;INTERACTION WITH SH2D1A
    6. 6.
      "Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival."
      Harrington A.W. , St Hillaire C. , Zweifel L.S. , Glebova N.O. , Philippidou P. , Halegoua S. , Ginty D.D.
      Cell146:421-434(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NGF AND NTF3 SIGNALING;ENZYME REGULATION;SUBCELLULAR LOCATION
    7. 7.
      "p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
      Baeza-Raja B. , Eckel-Mahan K. , Zhang L. , Vagena E. , Tsigelny I.F. , Sassone-Corsi P. , Ptacek L.J. , Akassoglou K.
      J. Neurosci.33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
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